Fig 2.

Relative growth rates (%) of D10^mut versus D10^wt at different concentrations of CQ, AQ, and DEAQ (nM). The maximum growth rate for D10^mut without drug exposure was based on the relative fitness (w = 0.89). The other plots are based on the IC₂₀, IC₅₀, and IC₉₀ values. The trend line intercept indicates the breakpoint where the drug resistance benefit equals the fitness cost of pfmdr1 1246Y. Area A represents the fitness cost, and area B represents the drug resistance benefit of pfmdr1 1246Y over the full concentration range.