Fig 4.

Survival curves in mice inoculated intravenously with C. neoformans H99 at 0.54 × 10⁵ to 6.1 × 10⁵ CFU/animal. Treatment with miltefosine (MTF) began at 1 h postchallenge, while fluconazole (FLC) and amphotericin B (AMB) were started 1 day after infection. Therapy with miltefosine at doses of 1.8, 3.6, and 7.2 mg/kg continued through day 4, and therapy with miltefosine at 15 and 45 mg/kg, fluconazole, and amphotericin B continued through day 10 (n = 10 mice per group). *, P < 0.05 for median survival compared to untreated controls; §, P < 0.05 for percent survival at study endpoint compared to untreated controls.