Table 1.

Binding to and inhibition of HCV NS5B GT 1b-con-1 polymerase by GS-9669 and other reference NNIs

Compound	Avg wild-type KD (nM) ± SDa	M423T KD fold shiftb	Mean wild-type IC50 (nM) ± SDc	M423T IC50 fold shiftd
GS-9669	1.35 ± 0.49	10.5	40 ± 17	4
Lomibuvir	2.21 ± 0.66	10.3	55 ± 17	4
Filibuvir	31.5 ± 14.4	950	73 ± 4	>94

^aAverage kinetic parameters across three surfaces extracted by using a global fit of a 1:1 binding model.

^bRatio of mutant K_D (equilibrium dissociation constant) over wild-type K_D values.

^cArithmetic mean of data from at least two experiments.

^dRatio of mutant IC₅₀ over wild-type IC₅₀ values.