Table 1.
Compound | Avg wild-type KD (nM) ± SDa | M423T KD fold shiftb | Mean wild-type IC50 (nM) ± SDc | M423T IC50 fold shiftd |
---|---|---|---|---|
GS-9669 | 1.35 ± 0.49 | 10.5 | 40 ± 17 | 4 |
Lomibuvir | 2.21 ± 0.66 | 10.3 | 55 ± 17 | 4 |
Filibuvir | 31.5 ± 14.4 | 950 | 73 ± 4 | >94 |
Average kinetic parameters across three surfaces extracted by using a global fit of a 1:1 binding model.
Ratio of mutant KD (equilibrium dissociation constant) over wild-type KD values.
Arithmetic mean of data from at least two experiments.
Ratio of mutant IC50 over wild-type IC50 values.