Table 3.
Compound | Mean EC50 (nM) for WT (GT 1b) ± SDa | Fold resistanceb against NS5B mutant |
|||||
---|---|---|---|---|---|---|---|
M423T | M423I | M423V | I482L | R422K | L419M | ||
GS-9669 | 11 ± 1.9 | 3.4 | 7.2 | 12 | 38 | 36 | 19 |
Lomibuvir | 11 ± 3.0 | 81 | 40 | 33 | 105 | 105 | 24 |
Filibuvir | 80 ± 28 | 37 | 31 | 37 | 17 | NT | NT |
2′-C-Me-A | 206 ± 86 | 0.8 | 0.7 | 0.4 | 0.6 | 0.7 | 1.2 |
Arithmetic means of data from at least two experiments Values were generated in a 96-well assay manual format. WT, wild type.
Fold resistance is calculated as the ratio of mutant EC50 to wild-type EC50 values. NT, not tested.