Table 7.

Pharmacokinetic parameters for GS-9669 across species

Dosage route and parameterc	Mean value ± SD for species
	Sprague-Dawley rat	Beagle dog	Cynomolgus monkey	Rhesus monkey
Intravenousa
Vss (liters/kg)	0.31 ± 0.09	0.68 ± 0.48	0.58 ± 0.10	0.70 ± 0.52
CL (liters/h/kg)	0.15 ± 0.11	0.46 ± 0.10	0.93 ± 0.04	1.09 ± 0.43
t1/2 (h)	3.33 ± 0.53	2.35 ± 1.13	2.33 ± 0.28	2.46 ± 1.60
Oralb
Tmax (h)	0.83 ± 0.29	0.5 ± 0.0
t1/2 (h)	2.69 ± 0.79	4.51 ± 1.41
F (%)	34 ± 32	49 ± 15

^aInfusion of 0.5 mg/kg.

^bOral gavage of a solution of 2 mg/kg.

^cV_ss, volume of distribution at steady state; CL, clearance; t_1/2, half-life; T_max, time to maximum concentration of drug in serum.