Table 7.
Dosage route and parameterc | Mean value ± SD for species |
|||
---|---|---|---|---|
Sprague-Dawley rat | Beagle dog | Cynomolgus monkey | Rhesus monkey | |
Intravenousa | ||||
Vss (liters/kg) | 0.31 ± 0.09 | 0.68 ± 0.48 | 0.58 ± 0.10 | 0.70 ± 0.52 |
CL (liters/h/kg) | 0.15 ± 0.11 | 0.46 ± 0.10 | 0.93 ± 0.04 | 1.09 ± 0.43 |
t1/2 (h) | 3.33 ± 0.53 | 2.35 ± 1.13 | 2.33 ± 0.28 | 2.46 ± 1.60 |
Oralb | ||||
Tmax (h) | 0.83 ± 0.29 | 0.5 ± 0.0 | ||
t1/2 (h) | 2.69 ± 0.79 | 4.51 ± 1.41 | ||
F (%) | 34 ± 32 | 49 ± 15 |
Infusion of 0.5 mg/kg.
Oral gavage of a solution of 2 mg/kg.
Vss, volume of distribution at steady state; CL, clearance; t1/2, half-life; Tmax, time to maximum concentration of drug in serum.