Table 3.
Mutations in the RT gene at key positions associated with NNRTI resistancea
| Subtype | No. of strains | L100 | K101 | K103 | V106 | V108 | Y181 | Y188 | G190 | P225 |
|---|---|---|---|---|---|---|---|---|---|---|
| A3 | 3 | P1, E1 | N1 | I1 | A1 | |||||
| B | 2 | N1 | ||||||||
| C | 5 | N2 | A2 | |||||||
| CRF01_AE | 1 | C1 | C1 | |||||||
| CRF02_AG | 43 | I2 | N21 | I7 | C1, C/Y1 | L2 | A3, A/G1 | H3 | ||
| CRF02_AG/A | 2 | N2 | C1 | H2 | ||||||
| CRF02_AG/A3 | 3 | N1 | ||||||||
| CRF02_AG/CRF06_cpx | 1 | |||||||||
| CRF02_AG/U/CRF02_AG | 1 | N1 | ||||||||
| CRF06_cpx | 4 | N1 | C1 | |||||||
| CRF09_cpx | 1 | |||||||||
| CRF09_cpx/CRF02_AG | 1 | |||||||||
| D | 2 | |||||||||
| G/CRF02_AG/A | 1 | N1 | I1 | |||||||
| CRF02_AG/C/A | 1 | C1 | L1 | |||||||
| CRF11_cpx/CRF02_AG | 1 | |||||||||
| Total | 72 | 2 | 2 | 31 | 10 | 6 | 3 | 7 | 5 |
a
For example, in N1, the letter represents the amino acid substitution and the number indicates the number of strains with that mutation.