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. 2012 Nov 22;41(2):881–899. doi: 10.1093/nar/gks1134

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Published by Oxford University Press 2012.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 5. — Depletion of RECQL5 in WRN-deficient fibroblasts induces an acute G₂/M arrest and severely affects cell survival. (A) Western blot analysis confirming AG11395 fibroblasts are WRN-deficient (upper panel). Depletion of RECQL5 in control (GM637) and WRN-deficient (AG11395) fibroblasts (lower panel). (B) Growth assays of RECQL5-depleted control and WRN-deficient fibroblasts. The number of cells were counted and plotted against number of days. The plot represents the mean of three independent experiments. (C) Depletion of RECQL5 in AG11395 fibroblasts shows prominent cell death and an acute G₂/M arrest by FACS analyses.