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. 2012 Nov 22;41(2):881–899. doi: 10.1093/nar/gks1134

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Published by Oxford University Press 2012.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 6. — Depletion of RECQL5 in WRN-deficient fibroblasts induces acute DNA damage and severe accumulation of DSBs. (A) Spontaneous accumulation of 53BP1 foci in both RECQL5-depleted control and WRN-deficient fibroblasts. (B) Plot showing the average number of 53BP1 foci/cells in RECQL5-depleted control and WRN fibroblasts. The data points represent the mean of three independent experiments.