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. 2012 Dec 18;41(2):842–854. doi: 10.1093/nar/gks1255

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 7. — Proposed model for the NIPP1-mediated regulation of EZH2 chromatin association by reversible phosphorylation. PP1 dephosphorylates EZH2 on TP-motifs. The CDK-mediated phosphorylation of EZH2 on TP5 (T416) results in the recruitment of NIPP1, which inhibits PP1. This enables the net phosphorylation of EZH2 on other TP-dipeptide motifs, including TP3 (T345), which was previously shown to mediate EZH2 binding to chromatin. The NIPP1-regulated phosphorylation of EZH2 is required for its recruitment to target genes that are implicated in proliferation and contributes to their silencing.