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Models for TREX recruitment. In model (I), UAP56 recruited to the pre-mRNA is released upon completion of splicing. Subsequently, Aly, UAP56 and THO are recruited to the spliced mRNA as a preformed particle. In model (II), UAP56 recruited to the pre-mRNA is transferred to the spliced mRNA, where it forms TREX together with Aly and THO recruited by CBC. See ‘Discussion’ section for details.
