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. 2012 Nov 17;41(2):e42. doi: 10.1093/nar/gks951

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 8. — Subnetworks identified from (a) Loi et al. (2008) and (b) Symmans et al. (2010). Subnetworks are merged if more than two genes are common. Node shape indicates the seed gene (hexagon) or non-seed gene (ellipse). Node color indicates the fold change between ‘early recurrence’ and ‘late recurrence’ groups. Red represents overexpressed in ‘early recurrence’ group and green reflects overexpressed in ‘late recurrence’ group. Enriched pathways and GO functional annotations are: (a) EGF signalling pathway: P = 3.35 e-11; MAPKinase signalling pathway: P = 7.00 e-08; ErbB signalling pathway: P = 7.00 e-08. (b) MAPKinase signalling pathway: P = 7.00 e-08; ErbB signalling pathway: P = 7.00 e-08; EGF signalling pathway: P = 1.84 e-04.