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. 2012 Nov 26;41(2):1047–1057. doi: 10.1093/nar/gks1180

Figure 1.

Figure 1.

Eukaryotic and archaeal e/aIF2. (A) Cartoon representation of Ss-aIF2 in complex with GDPNP and Met-tRNAfMet. The cartoon was drawn from PDB ID 3V11 (15). The color code is as follows: G-domain of γ (γDI, 1–210) in green, domain II (γDII, 211–327) in yellow, domain III (γDIII, 328–415) in orange, domain 1 of α in dark blue (αD1, 1–85), domain 2 of α in blue (αD2, 86–174), domain 3 of α in cyan (αD3, 175–266). The N-terminal α helix of the β subunit (3–19) anchored to γDI is colored in pink. Note that the position of the rest of the β subunit (residues 33–139, encircled with a dotted line) is only a tentative model, derived from SAXS data (15). The figure was drawn with PyMOL (http://www.pymol.org). (B) Schematic structural organizations of e/aIF2 α and β subunits. The colored boxes indicate the structural domains. Specific eukaryotic domains and extensions are colored in orange. Gray bars symbolize the K-boxes in the N-terminal domain of yeast eIF2β.