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Free-energy profiles as a function of the pseudo-dihedral angle phi (Supplementary Figure S7) from PMF calculations over the sampling range of 0.5–3 ns for G*CT-FABP, G*CA-FABP, G*CT-FAF, G*CA-FAF, G*CT-FAAF and G*CA-FAAF modified sequences (red and blue) and the unmodified GCT and GCA (black).
