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. 2013 Feb;195(3):585–595. doi: 10.1128/JB.01961-12

Fig 1.

Fig 1

Section of the proposed pathway of cholate (compound I) degradation in Pseudomonas sp. strain Chol1. The following compounds have been identified: II, 3-ketocholate; III, Δ1/4-3-ketocholate (the position of the double bond has not been identified yet; for simplicity, only the more probable Δ4 isomer was chosen); IV, Δ1,4-3-ketocholate; V, cholyl-CoA; VI, 3-ketocholyl-CoA; VII, Δ1/4-3-ketocholyl-CoA; VIII, Δ1,4-3-ketocholyl-CoA; IX, CoA ester of (22E)7α,12α-dihydroxy-3-oxochola-1,4-triene-24-oate (DHOCTO); XI, 7α,12α-dihydroxy-3-oxopregna-1,4-diene-20S-carbaldehyde (DHOPDCA); XII, 7α,12α-dihydroxy-3-oxopregna-1,4-diene-20-carboxylate (DHOPDC); XIII, CoA ester of DHOPDC; XVI, 7α,12α-dihydroxy-androsta-1,4-diene-3,17-dione (12α-DHADD); XVII, 7α-hydroxy-androsta-1,4-diene-3,12,17-trione (HADT); XVIII, 12β-DHADD; XIX, 3,7,12-trihydroxy-9,10-secoandrosta-1,3,5(10)triene-9,17-dione (THSATD); XX, DHOCTO; and XXI, 7α,12α22-trihydroxy-3-oxochola-1,4-diene-24-oate (THOCDO). The compounds shown in brackets are plausible intermediates that have not been detected yet.