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. 2012 Nov 21;40(Pt 6):1398–1403. doi: 10.1042/BST20120199

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© 2012 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The functions of Rab proteins in tumour cells include delivery and recycling of integrins at the front during cell migration, secretion of proteases to degrade the ECM and invade the surrounding tissues, secretion of exosomes that mediate the communication with stromal cells, trafficking of receptors and control of their signalling, impact on cell cycle and survival, and resistance to anticancer drugs.