Fig 6.

Intranasal inoculation of mice with VSV-12′GFP. VSV is often lethal in young mice when delivered through an olfactory entry route. A total of 50,000 PFU of either VSV-G/GFP or attenuated VSV-12′GFP was administered intranasally to young 16-day-old mice. Of the mice inoculated with VSV-G/GFP, 9 of 10 failed to gain body weight (B) and ultimately succumbed (A). In contrast, littermates receiving an equal dose of VSV-12′GFP steadily gained weight, and no mortality was observed. The number of mice inoculated with virus is indicated (n = 10), and error bars represent the standard errors of the means.