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Trimer electrostatics. TBEV, DENV1, DENV2, SLEV (E) and SFV (E1) envelope surface representations are colored based on surface potential, with red as negative potentia and blue as positive. The top panel is a top-down view of the fusion loops, and the bottom panel is a side view. SLEV and SFV have regions of negative charge that may be relevant to trimer structure or assembly (circled in black). The basic platform beneath flavivirus fusion loops is also labeled in panel D.
