Table 1.
Increased expression of genes related to IFN signaling in MeV-infected TG relative to NT mice, 5 days p.i.a
| Gene product | GenBank accession no. | Description | (TGi − NTi) − (TGu − NTu) |
TGi − TGu |
NTi − NTu |
|||
|---|---|---|---|---|---|---|---|---|
| Fold change | P | Fold change | P | Fold change | P | |||
| CHUK | AU045682 | Conserved helix-loop-helix ubiquitous ligase; IκB kinase alpha | 1.3 | 9.9E−4 | 1.2 | 4.5E−4 | — | — |
| STAT-1 | AW214029 | Signal transducer and activator of transcription | 1.9 | 3.1E−3 | 6.9 | 1.3E−12 | 3.5 | 1.5E−9 |
| USP18 | NM_011909 | Ubiquitin-specific peptidase 18 | 1.9 | 2.3E−2 | 21.9 | 3.8E−14 | 11.3 | 6.6E−12 |
| TGTP | NM_011579 | T cell-specific GTPase (inducible in T cells and macrophages) | 2.3 | 1.2E−2 | 5.1 | 1.5E−7 | 2.2 | 1.9E−3 |
| IFIT1L | NM_008331 | IFN-induced protein with tetratricopeptide repeats 1-like | 1.9 | 2.4E−2 | 27.7 | 8.7E−15 | 14.3 | 1.1E−12 |
| IFI27 | AY090098 | IFN-α-inducible protein 27 | 1.6 | 4.4E−2 | 6.7 | 5.2E−12 | 4.3 | 1.2E−9 |
| RIG-I | BB401061 | Retinoic acid-inducible gene I | 1.6 | 2.7E−2 | 2.2 | 6.7E−6 | 1.4 | 2.3E−2 |
| IRF7 | NM_016850 | IFN regulatory factor 7 | 1.7 | 5.0E−2 | 4.7 | 1.8E−8 | 2.7 | 1.6E−5 |
| IRF9 | NM_008394 | IFN regulatory factor 9 | 1.4 | 2.2E−2 | 2.8 | 6.6E−11 | 2.0 | 6.7E−8 |
| RNase L | BF714880 | 2′,5′-oligoadenylate synthetase-dependent RNase L | 1.3 | 6.2E−4 | 1.4 | 7.4E−7 | — | — |
a
Results are based upon transcriptome analysis of total brain RNA. All changes represent induction, and the absence of a significant difference is indicated by a dash. Superscript “i” and “u” represent infected and uninfected mice, respectively.