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In vivo replication of HIVJR-CSF and HIVJR-CSF K65R after i.p. injection into humanized mice shows no overt difference in replication capacity. Humanized NOD/SCID/γ−/− mice (28, 29) were infected with equal amounts of either HIV-1JR-CSF or HIV-1JR-CSF K65R (3 × 104 TCIU) by i.p. injection. The course of infection was monitored by determining plasma viral loads. Dotted line indicates the limit of detection of the assay.
