Table 1.
Dose | Vaccination |
Challenge |
||||
---|---|---|---|---|---|---|
Virus | Dosage | Route | Virus | Dosage | Route | |
Low | DVX (n = 3) | 2E5 PFU | m.p. | MPXV (n = 3) | 2E5 PFU | i.n. |
Acam (n = 3) | 2E5 PFU | m.p. | MPXV (n = 3) | 2E5 PFU | i.n. | |
PBS (n = 3) | NAa | m.p. | MPXV (n = 3) | 2E5 PFU | i.n. | |
High | DVX (n = 8) | 2E5 PFU | m.p. | MPXV (n = 4) | 2E6 PFU | i.n. |
Acam (n = 9) | 2E5 PFU | m.p. | MPXV (n = 7) | 2E6 PFU | i.n. | |
2X Imvamune (n = 10) | 1E8 TCID/1E8 TCID | s.c. | MPXV (n = 8) | 2E6 PFU | i.n. | |
PBS (n = 1) | NA | m.p. | MPXV (n = 1) | 2E6 PFU | i.n. |
‖NA, not applicable.