Inflammatory responses and energy metabolism were changed in Jα18 KO mice. (A) Relative levels of CD11c, SAA, TNF-α, and IL-6 transcripts in epididymal adipose tissue by qRT-PCR; (B) relative levels of adiponectin (AdipoQ) and GLUT4 mRNA in epididymal adipose tissue by qRT-PCR; (C) serum TNF-α concentration; (D) mRNA levels of PPARα, Tfam, NRF-1, ATGL, HSL, CGI-58 in epididymal adipose tissue of HFD-fed (4 weeks) WT and Jα18 KO mice. *, P < 0.05; **, P < 0.01; ***, P < 0.001, HFD WT versus HFD KO.