Fig 1.
The AU content of 5′ UTRs correlates with NF45-dependent IRES activity. (A) Diagonal plot of the AU content of human 5′ UTRs and IRES. We showed previously (7) that NF45 expression does not affect Bcl-xL, DAP5, APAF1, or VCIP IRES activities, but it does impact the cIAP1 IRES. (B) List of IRES-containing human mRNAs that have a >50% AU content within their 5′ UTRs. The percent AU content of the minimal IRES is indicated in brackets (if unknown, the content is equivalent to that of the 5′ UTR).