Fig 1.

Schematic representation of the amino acid sequence of the TP, IP, and chimeric receptors. (A) Secondary structure representation of the TP and IP amino acid sequences. The intracellular loop (ICL) regions replaced in the TP are indicated by dashed lines. (B) The amino acid sequences of the TP replaced by the IP sequence are underlined. TP ICL1-IP represents the TP with its first ICL replaced by the IP ICL1. Similarly, TP ICL2-IP represents the TP with its second ICL replaced by the IP ICL2; TP ICL3-IP represents the TP with its third ICL replaced by the IP ICL3; TP ICL2B-ΔYLYAQ-IP represents the TP ICL2B-IP receptor with the pentapeptide YLYAQ sequence deleted.