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DJ-1 directly binds to the p53 DNA-binding region. (A) Schematic diagram of p53 deletion mutants. FL, full-length; CT, C terminus; DBD, DNA-binding domain. (B) GST and GST–DJ-1 were incubated with 35S-labeled p53 in the presence or absence of H2O2 and then subjected to pulldown assays. (C) GST, GST–DJ-1, and GST-C106S DJ-1 were incubated with 35S-labeled p53-DBD and subjected to pulldown assays. (D) ELISAs were carried out using GST-p53, GST, DJ-1, and C106S DJ-1.
