Table 2.
Top 20 significantly regulated genes with the strongest correlation with muscle mass in each of clusters 3, 4, and 5
| Symbol | Description | Adjusted P value | AUC | Log2 fold change vs 6 mo |
R vs: |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 12 mo | 18 mo | 21 mo | 24 mo | 27 mo | Cluster | Mass | age | ||||
| Cluster 3 | |||||||||||
| Sirpa | Signal-regulatory protein alpha | 5.6E–21 | 4.1 | 0.3 | 0.5 | 0.7 | 1.6 | 2.2 | 1.00 | −0.95 | 0.91 |
| Tspan13 | Tetraspanin 13 | 1.2E–19 | 2.3 | 0.1 | 0.3 | 0.4 | 1.0 | 1.2 | 1.00 | −0.94 | 0.90 |
| Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | 8.6E–21 | 2.3 | 0.1 | 0.3 | 0.4 | 0.9 | 1.3 | 1.00 | −0.94 | 0.90 |
| Hmgn2 | High-mobility group nucleosomal binding domain 2 | 2.3E–19 | 1.9 | 0.1 | 0.2 | 0.3 | 0.8 | 1.1 | 1.00 | −0.94 | 0.87 |
| Rb1 | Retinoblastoma 1 | 2.7E–19 | 1.8 | 0.1 | 0.3 | 0.3 | 0.7 | 1.0 | 0.99 | −0.94 | 0.92 |
| Ccni | Cyclin I | 6.8E–20 | 1.5 | 0.2 | 0.1 | 0.2 | 0.6 | 0.9 | 0.99 | −0.94 | 0.84 |
| Krt18 | Keratin 18 | 2.2E–22 | 6.4 | 0.0 | 0.7 | 1.1 | 2.7 | 3.7 | 1.00 | −0.93 | 0.89 |
| Mgmt | O-6-Methylguanine-DNA methyltransferase | 5.0E–23 | 4.9 | 0.3 | 0.5 | 0.9 | 2.1 | 2.4 | 0.99 | −0.93 | 0.91 |
| Tmem38b | Transmembrane protein 38B | 6.0E–24 | 3.4 | 0.0 | 0.3 | 0.7 | 1.5 | 1.7 | 0.98 | −0.93 | 0.91 |
| Fst | Follistatin | 1.4E–17 | 3.3 | 0.2 | 0.3 | 0.5 | 1.5 | 1.9 | 1.00 | −0.93 | 0.88 |
| Cd151 | CD151 molecule (Raph blood group) | 1.7E–21 | 2.4 | 0.2 | 0.2 | 0.5 | 1.0 | 1.2 | 0.99 | −0.93 | 0.92 |
| Cd63 | Cd63 molecule | 2.9E–22 | 2.2 | 0.1 | 0.2 | 0.5 | 0.9 | 1.1 | 0.99 | −0.93 | 0.91 |
| Iffo1 | Intermediate filament family orphan 1 | 4.0E–15 | 2.0 | 0.1 | 0.2 | 0.3 | 0.8 | 1.2 | 1.00 | −0.93 | 0.88 |
| Slain2 | SLAIN motif family, member 2 | 6.6E–22 | 1.9 | 0.0 | 0.2 | 0.3 | 0.8 | 1.1 | 1.00 | −0.93 | 0.88 |
| Adcy2 | Adenylate cyclase 2 (brain) | 2.1E–17 | 1.7 | 0.1 | 0.3 | 0.2 | 0.8 | 1.0 | 0.99 | −0.93 | 0.86 |
| Ppp1r14b | Protein phosphatase 1, regulatory (inhibitor) subunit 14B | 3.3E–20 | 1.6 | 0.1 | 0.1 | 0.3 | 0.6 | 0.9 | 0.99 | −0.93 | 0.88 |
| Prkar1a | Protein kinase, cAMP-dependent, regulatory, type I, alpha | 8.8E–20 | 1.4 | 0.0 | 0.0 | 0.3 | 0.7 | 0.9 | 0.98 | −0.93 | 0.85 |
| Sec62 | SEC62 homolog (S. cerevisiae) | 4.0E–18 | 1.3 | 0.1 | 0.2 | 0.3 | 0.5 | 0.6 | 0.99 | −0.93 | 0.92 |
| Nono | Non-POU domain containing, octamer-binding | 2.9E–18 | 1.3 | 0.1 | 0.1 | 0.3 | 0.5 | 0.7 | 0.99 | −0.93 | 0.90 |
| Dclk1 | Doublecortin-like kinase 1 | 6.7E–22 | 7.2 | 0.4 | 1.0 | 1.4 | 2.9 | 3.4 | 0.99 | −0.92 | 0.94 |
| Cluster 4 | |||||||||||
| Cdkn1a | Cyclin-dependent kinase inhibitor 1A | 6.0E–24 | 10.7 | 0.6 | 1.6 | 2.5 | 4.0 | 4.6 | 0.98 | −0.92 | 0.96 |
| B2 m | β2-Microglobulin | 6.0E–24 | 3.9 | 0.3 | 0.5 | 0.9 | 1.5 | 1.7 | 0.99 | −0.92 | 0.95 |
| Ftl | Ferritin, light polypeptide | 7.7E–23 | 3.3 | 0.3 | 0.4 | 0.7 | 1.3 | 1.6 | 0.99 | −0.92 | 0.93 |
| Slc40a1 | Solute carrier family 39 (iron-regulated transporter), member 1 | 3.7E–16 | 3.0 | 0.4 | 0.4 | 0.7 | 1.1 | 1.2 | 0.99 | −0.92 | 0.95 |
| Nedd4 | Neural precursor cell expressed, developmentally downregulated 4 | 8.3E–20 | 2.8 | 0.3 | 0.4 | 0.7 | 1.0 | 1.3 | 0.99 | −0.92 | 0.92 |
| Arpp19 | cAMP-regulated phosphoprotein 19 | 2.0E–20 | 2.4 | 0.1 | 0.2 | 0.6 | 1.0 | 1.3 | 0.99 | −0.92 | 0.92 |
| Ppia | Peptidylprolyl isomerase A (cyclophilin A) | 5.5E–20 | 1.8 | 0.2 | 0.2 | 0.4 | 0.7 | 0.9 | 1.00 | −0.92 | 0.93 |
| Snx1 | Sorting nexin 1 | 4.2E–19 | 1.4 | 0.1 | 0.1 | 0.3 | 0.6 | 0.7 | 0.99 | −0.92 | 0.93 |
| Hnrnpa3 | Heterogeneous nuclear ribonucleoprotein A3 | 6.4E–17 | 1.3 | 0.1 | 0.1 | 0.3 | 0.5 | 0.6 | 1.00 | −0.92 | 0.92 |
| Ninj1 | Ninjurin 1 | 1.1E–19 | 3.1 | 0.2 | 0.4 | 0.7 | 1.2 | 1.6 | 0.99 | −0.91 | 0.93 |
| Hspb8 | Heat shock protein B8 | 9.4E–23 | 3.0 | 0.2 | 0.3 | 0.7 | 1.1 | 1.5 | 0.99 | −0.91 | 0.94 |
| Rpl3 | Ribosomal protein L3 | 3.8E–20 | 2.7 | 0.3 | 0.3 | 0.6 | 1.0 | 1.2 | 1.00 | −0.91 | 0.92 |
| Tmem30a | Transmembrane protein 30A | 2.5E–15 | 1.2 | 0.1 | 0.1 | 0.3 | 0.5 | 0.6 | 1.00 | −0.91 | 0.93 |
| Prrt4 | Proline-rich transmembrane protein 4 | 2.8E–21 | 7.4 | 0.5 | 1.0 | 1.7 | 2.8 | 3.4 | 0.99 | −0.90 | 0.95 |
| Ostalpha | Organic solute transporter alpha | 3.6E–16 | 5.1 | 0.4 | 0.7 | 1.1 | 1.9 | 2.4 | 0.99 | −0.90 | 0.95 |
| Phlda3 | Pleckstrin homology-like domain, family A, member 3 | 2.4E–20 | 4.3 | 0.2 | 0.5 | 0.9 | 1.7 | 2.0 | 0.99 | −0.90 | 0.94 |
| Tp63 | Tumor protein p63 | 8.3E–20 | 3.4 | 0.1 | 0.4 | 0.8 | 1.4 | 1.6 | 0.98 | −0.90 | 0.95 |
| Asgr2 | Asialoglycoprotein receptor 2 | 7.3E–16 | 2.8 | 0.3 | 0.4 | 0.6 | 1.1 | 1.3 | 0.99 | −0.90 | 0.94 |
| Tubb5 | Tubulin, beta 5 | 4.1E–21 | 2.6 | 0.2 | 0.3 | 0.6 | 1.0 | 1.2 | 0.99 | −0.90 | 0.94 |
| App | Amyloid beta (A4) precursor protein | 4.2E–21 | 2.5 | 0.3 | 0.2 | 0.6 | 1.0 | 1.2 | 0.99 | −0.90 | 0.90 |
| Cluster 5 | |||||||||||
| Stxbp1 | Syntaxin binding protein 1 | 3.4E–19 | 2.8 | 0.3 | 0.5 | 0.5 | 1.0 | 1.3 | 0.99 | −0.93 | 0.95 |
| Il6st | Interleukin-6 signal transducer | 4.9E–18 | 2.4 | 0.3 | 0.4 | 0.5 | 0.8 | 1.1 | 0.99 | −0.93 | 0.96 |
| Creld1 | Cysteine-rich with EGF-like domains 1 | 5.8E–16 | 2.1 | 0.2 | 0.4 | 0.4 | 0.8 | 1.0 | 0.99 | −0.91 | 0.93 |
| Tmem111 | Transmembrane protein 111 | 2.3E–17 | 1.7 | 0.2 | 0.3 | 0.4 | 0.7 | 0.8 | 0.98 | −0.91 | 0.95 |
| Csnk1d | Casein kinase 1, delta | 1.6E–16 | 1.5 | 0.2 | 0.2 | 0.2 | 0.5 | 0.7 | 0.98 | −0.91 | 0.91 |
| Ids | Iduronate 2-sulfatase | 2.3E–15 | 1.1 | 0.1 | 0.2 | 0.2 | 0.4 | 0.5 | 0.99 | −0.91 | 0.95 |
| Chrna1 | Cholinergic receptor, nicotinic, alpha 1 (muscle) | 9.4E–23 | 11.6 | 0.4 | 1.9 | 2.6 | 4.4 | 5.1 | 0.97 | −0.90 | 0.96 |
| Hdac4 | Histone deacetylase 4 | 1.1E–20 | 4.4 | 0.3 | 0.7 | 0.9 | 1.7 | 1.9 | 0.99 | −0.90 | 0.96 |
| Gsta3 | Glutathione S-transferase A3 | 9.7E–19 | 4.0 | 0.4 | 0.7 | 0.8 | 1.5 | 1.6 | 0.99 | −0.90 | 0.96 |
| Rab27a | RAB27A, member RAS oncogene family | 1.7E–13 | 2.5 | 0.3 | 0.4 | 0.5 | 0.9 | 1.2 | 0.99 | −0.90 | 0.94 |
| Ddr1 | Discoidin domain receptor tyrosine kinase 1 | 2.1E–15 | 1.9 | 0.1 | 0.3 | 0.4 | 0.7 | 0.9 | 0.99 | −0.90 | 0.95 |
| Prim1 | DNA primase, p49 subunit | 3.1E–15 | 1.5 | 0.0 | 0.3 | 0.3 | 0.6 | 0.7 | 0.97 | −0.90 | 0.95 |
| Runx1 | Runt-related transcription factor 1 | 5.7E–23 | 8.1 | 0.4 | 1.3 | 2.0 | 2.9 | 3.4 | 0.97 | −0.89 | 0.98 |
| Ltbp1 | Latent transforming growth factor beta binding protein 1 | 1.2E–17 | 4.7 | 0.5 | 0.9 | 0.9 | 1.5 | 2.1 | 0.99 | −0.89 | 0.96 |
| Plxnb2 | Plexin B2 | 1.7E–17 | 2.2 | 0.3 | 0.4 | 0.5 | 0.8 | 1.0 | 0.99 | −0.89 | 0.95 |
| Grina | Glutamate receptor, ionotropic, N-methyl d-aspartate-associated protein 1 (glutamate binding) | 1.8E–16 | 1.8 | 0.2 | 0.3 | 0.3 | 0.6 | 0.8 | 0.99 | −0.89 | 0.94 |
| Lrp4 | Low-density lipoprotein receptor-related protein 4 | 3.7E–13 | 1.4 | 0.1 | 0.3 | 0.2 | 0.5 | 0.8 | 0.96 | −0.89 | 0.92 |
| Sln | Sarcolipin | 1.2E–21 | 9.8 | 0.4 | 1.6 | 2.1 | 3.8 | 4.1 | 0.98 | −0.88 | 0.96 |
| Musk | Muscle, skeletal, receptor tyrosine kinase | 1.8E–17 | 3.9 | 0.1 | 0.6 | 0.8 | 1.5 | 1.7 | 0.98 | −0.88 | 0.96 |
| Abca1 | ATP-binding cassette, subfamily A (ABC1), member 1 | 1.6E–15 | 3.0 | 0.3 | 0.6 | 0.4 | 1.2 | 1.3 | 0.96 | −0.88 | 0.89 |