Fig 3.
RABV G-specific antibody isotypes produced at different times after immunization before and after virus challenge. Groups of Swiss Webster mice immunized i.m. with 105 FFU of live or UV-inactivated TriGAS or only PBS and infected 3 weeks (A to E), 3 months (F to J), or 6 months (K to O) later i.m. with 10 LD50s of DOG4 RABV were bled 7 days before and 5 days after virus challenge. Isotypes of RABV G-specific antibody were determined by ELISA as described in Materials and Methods. Values are mean titers (± the standard error [SE]) calculated from 10 mice per group.