Fig 6.

Mucosal inflammatory cytokines associated with SIV infection. GCF samples (two samples per animal) were taken from gingivitis (GVS; triangles) and control (CNT; circles) rhesus macaques on the day of SIV challenge (DOC) and at 2, 4, and 26 weeks post-SIV oral exposure (WPC). SIV-infected macaques are represented by filled symbols, while open symbols are uninfected macaques. Cytokine concentrations (in pg/ml) were determined in the GCF by an NHP Luminex assay as described in Materials and Methods. Differences in median cytokine concentrations were compared between groups with the Mann-Whitney test. ***, extremely significant, P < 0.001; **, very significant, 0.001 < P < 0.01; *, significant, 0.01 < P < 0.05; ns, not significant, P > 0.05.