Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model illustrating p53-mediated deregulation of p53AIP1 by HBx. In unstressed cells, a transcriptionally repressive p53–YY1–GATA-1–HDAC1 complex is bound to the p53AIP1 promoter, repressing p53AIP1 transcription. In the presence of HBx, PCAF-mediated p53 Lys320 acetylation is enhanced, endowing p53 with selectivity for the more conserved intron 1 RE. The transcriptionally activating HBx–PCAF–Ac-p53–Sp1 complex recruited to p53AIP1 intron 1 stimulates p53AIP1 transcription.
