Table 2.

Experimentally validated genes with HBx-altered p53 occupancy and corresponding gene expression from p53 ChIP-on-chip and expression profiling^a

Gene no.	Gene product name	p53 occupancy (ChIP-on-chip)		Gene expressionb
		Binding pattern	p53 binding (MAT scorec)	Fold change (HBx/control)	P value
1	p53AIP1	Decrease	−15.17	1.66	5.0E−02
2	SPINK6		−9.12	3.10	1.0E−02
3	DUX4		−4.98	−1.50	1.0E−03
4	ERCC2		−14.42	1.01	9.7E−01
5	C1D		−12.10	1.00	9.2E−01
6	FAS	Increase	7.20	2.11	4.5E−08
7	ABCD2		6.30	1.62	4.0E−02
8	AKT1S1		6.00	−2.51	4.0E−03
9	GDNF		4.00	−1.44	2.0E−03
10	HNF4		10.60	1.18	9.1E−01
11	TNP1		4.40	1.11	8.8E−01
12	SLC7A13	Shift	−13.80	1.61	4.0E−02
			4.20
13	UNKL		−4.30	−1.57	2.0E−03
			4.00
14	KALRN		−9.80	−1.11	9.6E−01
			5.10

^aSignificantly deregulated candidate genes (fold change, >1.5; P ≤ 0.05) with altered p53 binding are indicated in boldface.

^bItalics indicates significantly upregulated genes; underlining represents significantly downregulated genes.

^cMAT (model-based analysis of tiling arrays) score indicates ChIP-enriched regions (positive score, increased p53 binding; negative score, decreased p53 binding).