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. Author manuscript; available in PMC: 2013 Jan 24.
Published in final edited form as: Adv Exp Med Biol. 2011;716:14–28. doi: 10.1007/978-1-4419-9533-9_2

Figure 1.

Figure 1

Development of committed mast cell progenitors (MCp) in the bone marrow (BM) from the hematopoietic stem cell (HSC) and the molecules identified as playing a role in the trafficking of the these cells to the intestine and peritoneal cavity under basal, non-inflamed conditions. Two different developmental pathways have been proposed leading to the production of committed mast cell progenitors. These cells then move out to peripheral tissues via the circulation and migrate into the specific tissue sites such as the intestine and serosal cavity under the control of specific molecules such as the α4 integrins and various chemokine pathways. A role for the C3b and TPO receptors has been shown to affect mast cell numbers in the skin and peritoneal cavity. See text for details.