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. Author manuscript; available in PMC: 2014 Jan 18.

Published in final edited form as: Inorg Chem. 2013 Jan 2;52(2):1069–1076. doi: 10.1021/ic302379j

Time course of the ligand substitution of [Co(acacen)(X)₂]⁺ derivatives and 4MeIm (2 eq.) at pD 7.0 (A) and pD 5.5 (B) at 37 °C. 2 and 3 readily reacts with 4MeIm to form 1. Under acidic conditions, the formation of [Co(acacen)(4MeIm)(D₂O)]⁺ is observed in greater quantity and reducing the abundance of 1; this is consistent with the pD stability of 1. Complex 1 is a minor product (< 20%) for 4 and 5 at pD 7.0, and 4, 5, and 6 at pD 5.5. For 6, the extend of 1 formation is pD dependent due to the relative basicity of 4MeIm (pKa 7.4) and Py (pKa 5.5). = 2, = 3, = 4, = 5, = 6.

Inline graphic — Time course of the ligand substitution of [Co(acacen)(X)₂]⁺ derivatives and 4MeIm (2 eq.) at pD 7.0 (A) and pD 5.5 (B) at 37 °C. 2 and 3 readily reacts with 4MeIm to form 1. Under acidic conditions, the formation of [Co(acacen)(4MeIm)(D₂O)]⁺ is observed in greater quantity and reducing the abundance of 1; this is consistent with the pD stability of 1. Complex 1 is a minor product (< 20%) for 4 and 5 at pD 7.0, and 4, 5, and 6 at pD 5.5. For 6, the extend of 1 formation is pD dependent due to the relative basicity of 4MeIm (pKa 7.4) and Py (pKa 5.5). = 2, = 3, = 4, = 5, = 6.