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. 2013 Jan 17;36(2):394–402. doi: 10.2337/dc12-1112

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© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Mediation model: Overlapping brain regions mediate the effect observed between HOMA-IR and food craving in obese individuals. A: Correlation between HOMA-IR levels and food craving ratings in the obese and lean groups. B: Overlapping regions of neural activation. C: Diagram representation of the mediation model of HOMA-IR, regional brain activation, and food craving in obese individuals. Overlap brain maps for each condition were generated from individual maps during the three conditions that were thresholded at P < 0.05, FWE corrected, and that examined within each condition the correlations between 1) brain activation and HOMA-IR values and 2) brain activation and subjective food craving values. A cluster size of 108 was subsequently applied the overlap maps. Talairach z levels are indicated. Subjective food craving correlation brain maps overlapped with HOMA-IR correlation brain maps in the obese group in the three conditions (favorite-food cue, stress cue, and neutral-relaxing cue).

Mediation model: Overlapping brain regions mediate the effect observed between HOMA-IR and food craving in obese individuals. A: Correlation between HOMA-IR levels and food craving ratings in the obese and lean groups. B: Overlapping regions of neural activation. C: Diagram representation of the mediation model of HOMA-IR, regional brain activation, and food craving in obese individuals. Overlap brain maps for each condition were generated from individual maps during the three conditions that were thresholded at P < 0.05, FWE corrected, and that examined within each condition the correlations between 1) brain activation and HOMA-IR values and 2) brain activation and subjective food craving values. A cluster size of 108 was subsequently applied the overlap maps. Talairach z levels are indicated. Subjective food craving correlation brain maps overlapped with HOMA-IR correlation brain maps in the obese group in the three conditions (favorite-food cue, stress cue, and neutral-relaxing cue).