FIG. 7.

Schematic representation of liver ERα signaling with regard to the regulation of liver glucose and lipid metabolism: HFD feeding after OVX resulted in pathway-selective insulin resistance where insulin failed to suppress hepatic glucose production (HGP), yet insulin was able to promote liver triglyceride (TG) storage by reducing hepatic apoB content, dephosphorylating ACC, and suppressing tracer incorporation into serum triglyceride. Estrogen treatment after OVX improved insulin suppression of hepatic glucose production and blocked insulin-mediated liver triglyceride storage.