FIG. 3.

Validation of CLIP-CHIP data at the protein level by immunofluorescence in NOD samples. Immunofluorescence staining of NOD 21-week-old pancreas sections for cathepsin C (A), cathepsin S (B), and cathepsin W (C) shows localization at sites where peri-islet BM staining is lost (arrows), as shown here by laminin (LM) γ1 staining. The boxed areas are shown at higher magnification to the right. Scale bars are 100 μm. (A high-quality digital representation of this figure is available in the online issue.)