FIG. 6.

RAGE deficiency is associated with decrease in body weight (A), adipose tissue weight (B), and adipocyte size (C) in mice. A: Increase in body weight induced by high-fat diet (HF) is suppressed in RAGE^−/− mice at 15 and 20 weeks of age. B: Epididymal adipose tissues were isolated from WT and RAGE^−/− mice fed either with normal (N) or HF diet at 15 and 20 weeks of age, and tissue weight was determined. All columns represent mean ± SD. C: Epididymal adipose tissues were isolated from WT or RAGE^−/− mice at 20 weeks fed with HF diet, and adipocyte size was determined histochemically. Columns represent mean ± SD. *P < 0.05 vs. WT mice. **P < 0.05 vs. normal diet, Student t test. Numbers of animals are shown in parentheses.