FIG. 1.

BIM-22493 treatment reduces food intake, body weight, and core body temperature and increases activity and energy expenditure in obese NHP. A: Administration of BIM-22493 (0.5 mg/kg/day) decreased food intake in the first 4 weeks. Upon termination of the treatment, a slight rebound hyperphagia can be observed during the washout period (weeks 9–12). The black bars are data from actively treated NHP, the cross-hatched bars are during vehicle treatment; the shaded area represents the 8-week treatment period. Body weight change in kilograms (B) and percentage (C) at specific time points during treatment with BIM-22493. Data (n = 12) were analyzed with repeated-measures ANOVA (P < 0.001). *Individually significant time points by Dunnett post hoc test (vs. vehicle). C: Data were analyzed by repeated measures ANOVA (P < 0.001) with Bonferroni post hoc test (weight loss at 8 weeks significantly different [**P < 0.01] vs. 2 and 12 weeks). D: Activity increases incrementally during treatment (P = 0.037 repeated-measures ANOVA over treatment period of 0–8 weeks). E: Energy expenditure as measured by double-labeled water is increased after treatment (P = 0.0134 paired Student t test compared with baseline). F: Core body temperature trended toward a decrease in response to BIM-22493. P = 0.0021 by repeated-measures ANOVA. *Individually significant time points by Dunnett post hoc test vs. vehicle.