FIG. 2.

BIM-22493 treatment reduced fat mass, leptin levels, lean mass, and triglycerides in obese NHP. A: Dual-energy X-ray absorptiometry scanning determined that total fat mass was reduced in diet-resistant (n = 3) and diet-sensitive animals (n = 9) after 8 weeks of BIM-22493 treatment compared with the baseline fat mass. This loss was maintained the 4-week washout (Wash) period of saline treatment. *P < 0.05, **P < 0.005 by paired Student t test compared with starting weight. B: Leptin levels drop accordingly with body fat loss after treatment (*P < 0.001) compared with vehicle (Veh) and rebounded slightly after 4 weeks of washout. C: The decrease in leptin shown in B after treatment correlates with the amount of body weight loss (r² = 0.6634, P = 0.0023). D: Triglyceride levels in serum drop during the drug treatment (shaded area). P = 0.0238 by ANOVA. *Individually significant by Dunnett post hoc test from vehicle. E: Lean mass was slightly reduced only in diet-sensitive animals after 8 weeks of treatment and maintained after 4 weeks of saline treatment (Wash). *P < 0.002 by paired Student t test compared with starting weight. F: Bone mineral content was not significantly altered from baseline at the end of the 8-week BIM 22493 treatment.