Table 4.

Odds ratios and 95% confidence/credible intervals for the four placebo comparisons and two select active intervention comparisons in the second illustrative example

Model	Trt1 vs Placebo	Trt2 vs Placebo	Trt3 vs Placebo	Trt4 vs Placebo	Trt2 vs Trt1	Trt4 vs Trt2
Random-effects pair wise meta-analysis
DerSimonian-Laird	1.94(1.67-2.24)	2.11(1.42-3.13)	1.78(1.60-1.97)	2.86(2.21-3.71)	1.90 (1.17-3.09)	--
Hartung-Makimbi	1.94(1.68-2.23)	2.09(1.42-3.09)	1.77(1.57-2.00)	2.86(2.21-3.70)	1.91 (1.16-3.13)	--
Bayesian (non-informative)	1.98(1.70-2.31)	2.38(1.30-5.82)	1.80(1.61-2.02)	2.89(2.08-4.06)	1.97 (0.66-8.88)	--
Bayesian (frequentist informed)	1.97(1.71-2.28)	2.16(1.48-3.68)	1.80(1.60-2.02)	2.89(2.23-3.77)	1.79 (1.17-3.55)	--
Bayesian (empirically informed)	1.97(1.71-2.28)	2.13(1.47-3.98)	1.80(1.61-2.03)	2.89(2.20-3.80)	1.84 (1.17-3.53)	--
Random-effects MTC models
Weakly informed variance models
Homogeneous variance model	1.91(1.67-2.19)	2.59(1.97-3.50)	1.80(1.57-2.08)	2.90(2.23-3.79)	1.36 (1.02-1.84)	1.11(0.74-1.63)
Unrestricted variances	1.95(1.69-2.28)	3.05(1.84-5.50)	1.81(1.62-2.01)	2.90(2.07-4.07)	1.56 (0.94-2.75)	0.94(0.49-1.74)
Exchangeable variances*	1.93(1.67-2.26)	2.89(1.98-4.43)	1.78(1.56-1.99)	2.89(2.17-3.86)	1.50 (1.03-2.26)	1.01(0.59-1.58)
Consistency variances structure	1.93(1.66-2.23)	2.80(1.92-4.69)	1.80(1.60-2.02)	2.90(2.18-3.86)	1.45 (0.99-2.40)	1.03(0.58-1.66)
Moderately informed variance models
Frequentist informed priors	1.93(1.68-2.22)	2.80(1.98-4.10)	1.80(1.60-2.03)	2.90(2.22-3.78)	1.46 (1.02-2.11)	1.05(0.66-1.61)
Empirically informed priors	1.93(1.67-2.23)	2.84(2.00-4.26)	1.80(1.61-2.02)	2.91(2.22-3.81)	1.48 (1.00-2.20)	1.02(0.63-1.59)

Abbreviations: DIC (Deviance information criterion); pD (effective number of model parameters); Trt (Treatment).