Table 1.
Mutational Analysis of a Melanoma Cell Line Panel
| Cell Lines | BRAF | NRAS | KRAS | HRAS | PTEN |
CDKN2A |
CDK4 | TP53 | |
|---|---|---|---|---|---|---|---|---|---|
| p16INK4A | p14ARF | ||||||||
| D35 |
wt |
wt |
wt |
wt |
wt |
c.151-1 G > A |
wt |
nd |
wt |
| UACC1118 |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
| UACC2837 |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
p.R342X |
| MM329 |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
| UACC2534 |
wt |
wt |
wt |
wt |
wt |
Deletion* |
wt |
wt |
wt |
| UACC1097 |
wt |
p.Q61K |
wt |
wt |
p.I50N |
p.H83Y |
p.A97V |
wt |
wt |
| M92-001 |
wt |
p.G13R |
wt |
wt |
wt |
Deletion* |
Deletion* |
wt |
wt |
| UACC3074 |
wt |
p.G13R |
wt |
wt |
wt |
p.P114L |
wt |
wt |
Deletion |
| UACC3093 |
wt |
p.Q61L |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
| UACC383 |
wt |
wt |
wt |
p.Q61R |
wt |
Deletion* |
Deletion* |
wt |
wt |
| UACC647 |
p.V600E |
wt |
wt |
wt |
Deletion* |
wt |
wt |
wt |
Deletion |
| UACC558 |
p.V600E |
wt |
wt |
wt |
c.802-1 G > C |
wt |
wt |
wt |
wt |
| MM200 |
p.V600E |
wt |
wt |
wt |
p.F56I |
wt |
wt |
wt |
wt |
| UACC903 |
p.V600E |
wt |
wt |
wt |
p.Y76X |
Deletion* |
Deletion* |
wt |
wt |
| BL |
p.V600E |
wt |
wt |
wt |
p.Q298X |
p.E88K |
p.G102E |
wt |
p.I195T |
| MM622 |
p.V600E |
wt |
wt |
wt |
p.L139X |
p.G67fs*53 |
p.R122fs*79 |
wt |
wt |
| NK14 |
p.V600E |
wt |
wt |
wt |
p.P38L |
p.R58X |
p.P72L |
wt |
wt |
| M91-054 |
p.V600E |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
| D17 |
p.V600E |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
| MM604 |
p.V600E |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
| MM170 |
p.V600E |
wt |
wt |
wt |
wt |
Deletion* |
Deletion* |
wt |
wt |
| UACC091 |
p.V600R |
wt |
wt |
wt |
wt |
Deletion* |
Deletion* |
wt |
p.R213X |
| MM229 |
p.L597S |
wt |
wt |
wt |
wt |
Deletion* |
Deletion* |
wt |
wt |
| WSB |
p.V600E |
wt |
wt |
wt |
wt |
Deletion* |
Deletion* |
wt |
wt |
| A375 |
p.V600E |
wt |
wt |
wt |
wt |
p.E61X; p.E69X |
c.1_316del316; p.G75V; p.G83V |
wt |
wt |
| MM540 |
p.V600E |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
p.S366P |
| SKMEL13 |
p.V600E |
wt |
wt |
wt |
wt |
Deletion* |
Deletion* |
wt |
p.R248W |
| UACC257 |
p.V600E |
wt |
wt |
wt |
wt |
p.P81L |
wt |
wt |
wt |
| WM35 |
p.V600E |
wt |
wt |
wt |
wt |
Deletion* |
Deletion* |
wt |
wt |
| UACC1022 |
p.L597S |
wt |
wt |
wt |
wt |
wt |
wt |
wt |
p.R196X |
| UACC1308 | p.V600E | wt | wt | wt | wt | wt | wt | wt | p.F134S |
wt = wildtype, * = homozygous, nd = not determined.