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. 2013 Jan 5;6:1. doi: 10.1186/1756-8935-6-1

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Copyright ©2013 Kassner et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Crosstalk between adenosine diphosphate-ribosyltransferase (ARTD)-1 and SET7/9-dependent modification of linker and core histones. (A) Summary of known post-translational modification sites of H1.4. The grey box marks the central globular domain. The six newly identified KAK motifs that are methylated by SET7/9 are highlighted in red. Blue: PARylation (PAR), red: phosphorylation (P), green: methylation (me, number indicates methylation state). (B) Model of the sequential adenosine diphosphate (ADP)-ribosylation and methylation reactions on histone H3 and H1 by ARTD1 and SET7/9.