Table 3.
Differential expression of genes encoding secretory pathway related proteins
| DSM code | DSM annotation | Fold-change B36/N402 | P | FDR |
|---|---|---|---|---|
|
Protein folding |
|
|
|
|
|
An02g14800* |
protein disulfide isomerase A pdiA – A. niger |
1.72 |
5.98E-08 |
3.43E-06 |
|
An18g02020* |
disulfide isomerase tigA – A. niger |
1.89 |
1.61E-08 |
1.17E-06 |
|
An01g04600* |
PDI related protein A prpA – A.niger |
2.08 |
2.21E-09 |
2.40E-07 |
|
An16g07620* |
strong similarity to endoplasmic reticulum oxidising protein Ero1 – S. cerevisiae |
1.97 |
1.02E-08 |
8.15E-07 |
|
An18g04260* |
similarity to secreted protein HNTME13 from patent WO9839446-A2 – H. sapiens |
2.46 |
1.06E-09 |
1.28E-07 |
|
An18g06470* |
strong similarity to DnaJ-like protein MTJ1 - Mus musculus |
1.48 |
1.34E-06 |
3.70E-05 |
| An05g00880* |
strong similarity to dnaJ protein homolog Scj1 – S. cerevisiae |
1.79 |
1.02E-07 |
5.04E-06 |
|
An01g08420* |
strong similarity to calcium-binding protein precursor clx1p – S. pombe |
2.42 |
8.96E-10 |
1.13E-07 |
| An04g02020* |
strong similarity to cyclophilin cypB – A. nidulans |
1.69 |
1.19E-07 |
5.60E-06 |
|
An01g06670* |
strong similarity to peptidyl-prolyl isomerase FKBP-21 – N. crassa |
1.66 |
4.71E-07 |
1.57E-05 |
|
An11g04180* |
dnaK-type molecular chaperone bipA – A. niger |
2.32 |
8.63E-10 |
1.11E-07 |
|
An01g13220* |
strong similarity to 150 kDa oxygen regulated protein ORP150 - Rattus norvegicus |
2.26 |
1.34E-09 |
1.58E-07 |
|
Signal recognition/cleavage |
|
|
|
|
| An04g06890 |
similarity to 72-kD protein of the signal recognition particle SRP72 - Canis lupus |
1.33 |
1.14E-04 |
1.37E-03 |
|
An15g06470* |
similarity to signal sequence receptor alpha chain - Canis lupus |
1.86 |
4.49E-08 |
2.72E-06 |
|
An01g00560* |
strong similarity to signal peptidase subunit Sec11 – S. cerevisiae |
1.84 |
5.70E-07 |
1.84E-05 |
|
An16g07390* |
strong similarity to endoplasmatic reticulum signal peptidase subunit Spc2 – S. cerevisiae |
1.90 |
7.99E-09 |
6.74E-07 |
|
An09g05420* |
similarity to signal peptidase subunit Spc3 – S. cerevisiae |
1.99 |
6.90E-09 |
6.03E-07 |
|
Translocation into ER |
|
|
|
|
|
An03g04340* |
strong similarity to ER membrane translocation facilitator Sec61 - Yarrowia lipolytica |
1.68 |
9.76E-08 |
4.90E-06 |
| An01g03820 |
strong similarity to ER protein-translocation complex subunit Sbh2 – S. cerevisiae |
1.62 |
2.60E-06 |
6.33E-05 |
|
An01g11630* |
strong similarity to translocation complex component Sss1 – S. cerevisiae |
1.71 |
1.88E-07 |
8.11E-06 |
|
An02g01510* |
strong similarity to component of the endoplasmic reticulum protein translocation machinery Sec62 – S. cerevisiae |
1.57 |
7.50E-06 |
1.49E-04 |
|
An01g13070* |
strong similarity to signal recognition particle receptor Sec63 – S. cerevisiae |
2.02 |
2.17E-08 |
1.47E-06 |
|
An16g08830* |
strong similarity to component of ER protein-translocation subcomplex Sec71 from patent WO9949028-A1 – S. cerevisiae |
1.80 |
3.47E-08 |
2.17E-06 |
| An15g01670 |
strong similarity to signal sequence receptor alpha subunit SRP101 - Yarrowia lipolytica |
1.29 |
1.14E-04 |
1.37E-03 |
| An05g00140* |
similarity to signal recognition particle receptor beta chain Srp102 – S. cerevisiae |
1.39 |
2.57E-05 |
4.16E-04 |
|
Glycosylation |
|
|
|
|
| An02g07650 |
strong similarity to phosphoglucomutase pgmB – A. nidulans |
0.80 |
5.29E-04 |
4.81E-03 |
|
An03g05940* |
strong similarity to glutamine-fructose-6-phosphate transaminase Gfa1 – S. cerevisiae |
0.66 |
2.20E-06 |
5.58E-05 |
|
An04g04990* |
strong similarity to mannose-1-phosphate guanyltransferase MPG1 - Trichoderma reesei |
1.46 |
1.44E-05 |
2.57E-04 |
|
An11g02380* |
strong similarity to GTP:alpha-D-mannose-1-phosphate guanylyltransferase MPG1 - Hypocrea jecorina |
1.35 |
5.47E-05 |
7.67E-04 |
|
An02g08660 |
strong similarity to hypothetical protein H04M03.4 - Caenorhabditis elegans |
1.25 |
2.90E-04 |
2.91E-03 |
| An03g06940* |
strong similarity to UPD-GlcNAc transporter MNN2-2 - Kluyveromyces lactis |
1.35 |
2.72E-05 |
4.38E-04 |
|
An02g14560* |
oligosaccharyltransferase alpha subunit OstA – A. niger |
2.05 |
2.27E-09 |
2.40E-07 |
|
An07g04190* |
strong similarity to dolichyl-diphospho-oligosaccharide--protein glycosyltransferase 48kD chain DDOST - Gallus gallus |
1.69 |
1.03E-07 |
5.04E-06 |
|
An18g03920* |
strong similarity to defender against apoptotic cell death DAD1 - Homo sapiens |
2.04 |
2.49E-09 |
2.56E-07 |
|
An02g14930* |
strong similarity to dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain Ost3 - S. cerevisiae |
1.47 |
1.51E-06 |
4.08E-05 |
|
An16g08570* |
strong similarity to translation initiation factor 3 47 kDa subunit stt3p – S. pombe |
1.78 |
2.74E-07 |
1.07E-05 |
|
An16g04330* |
strong similarity to mannose phospho-dolichol synthase dpm1 - Hypocrea jecorina |
1.63 |
2.72E-07 |
1.07E-05 |
| An01g05200* |
strong similarity to DPM2 - Mus musculus |
1.43 |
4.84E-05 |
6.98E-04 |
|
An03g04410* |
strong similarity to UDP-glucose:dolichyl-phosphate glucosyltransferase Alg5 – S. cerevisiae |
1.78 |
3.47E-07 |
1.26E-05 |
|
An02g03240* |
strong similarity to UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Alg7 – S. cerevisiae |
1.92 |
1.76E-08 |
1.24E-06 |
| An06g01100* |
strong similarity to mannosyltransferase Alg1 – S. cerevisiae |
1.27 |
1.50E-04 |
1.70E-03 |
|
An14g05910* |
strong similarity to mannosyltransferase Alg2 – S. cerevisiae |
1.93 |
2.28E-08 |
1.53E-06 |
| An18g05910* |
strong similarity to hypothetical glycosyl transferase SPCC330.08 – S. pombe |
1.49 |
7.14E-05 |
9.49E-04 |
|
An02g14940* |
strong similarity to human transmembrane protein HTMPN-23 from patent WO9961471-A2 - Homo sapiens |
1.49 |
2.62E-06 |
6.38E-05 |
|
An04g03130 |
strong similarity to mannosylation protein Lec35 - Cricetulus griseus [putative sequencing error] |
1.56 |
4.25E-07 |
1.46E-05 |
| An18g02360* |
strong similarity to Dol-P-Man dependent alpha(1–3) mannosyltransferase Alg3 – S. cerevisiae |
1.92 |
1.74E-08 |
1.24E-06 |
|
An08g07020* |
similarity to mannosyl transferase Alg9 – S. cerevisiae |
1.48 |
7.80E-06 |
1.53E-04 |
| An01g08460* |
strong similarity to the mannosyltransferase Alg12 – S. cerevisiae |
1.37 |
4.69E-04 |
4.36E-03 |
|
An02g12630* |
strong similarity to glucosyltransferase Alg6 - S. cerevisiae |
1.37 |
1.35E-05 |
2.44E-04 |
| An04g08820* |
strong similarity to glucosyltransferase Alg8 – S. cerevisiae |
1.24 |
3.24E-04 |
3.22E-03 |
| An02g02980* |
strong similarity to protein influencing Itr1 expression Die2 – S.s cerevisiae |
1.42 |
4.53E-05 |
6.58E-04 |
|
An15g01420* |
strong similarity to glucosidase I Cwh41 – S. cerevisiae |
1.81 |
2.90E-08 |
1.84E-06 |
| An18g05620 |
strong similarity to glucosidase II alpha subunit AAF66685.1 - Homo sapiens |
0.80 |
4.70E-04 |
4.37E-03 |
| An01g10930* |
strong similarity to enzyme with sugar transferase activity from patent JP11009276-A - Acremonium sp. |
0.45 |
2.27E-09 |
2.40E-07 |
| An04g06920* |
extracellular alpha-glucosidase aglU - Aspergillus niger |
0.60 |
7.55E-08 |
4.07E-06 |
|
An09g03300 |
strong similarity to alpha-xylosidase XylS - Sulfolobus solfataricus |
0.80 |
4.19E-04 |
3.98E-03 |
|
An09g05880* |
strong similarity to alpha-glucosidase ModA - Dictyostelium discoideum |
1.75 |
4.77E-08 |
2.86E-06 |
|
An13g00620* |
strong similarity to 80K protein H precursor G19P1 - Homo sapiens |
1.53 |
1.24E-06 |
3.47E-05 |
| An07g06430* |
strong similarity to glycoprotein glucosyltransferase gpt1p – S. pombe |
1.64 |
3.96E-07 |
1.39E-05 |
| An01g12550 |
strong similarity to mannosyl-oligosaccharide 1,2-alpha-mannosidase msdS – A. saitoi |
0.32 |
2.29E-11 |
8.76E-09 |
| An06g01510 |
strong similarity to class I alpha-mannosidase AAB62720.1 - Spodoptera frugiperda |
0.74 |
4.29E-05 |
6.31E-04 |
| An12g00340* |
similarity to alpha 1,2-mannosidase IB - Homo sapiens |
1.54 |
7.61E-06 |
1.50E-04 |
| An05g01750 |
strong similarity to alpha-1,6-mannosyltransferase Hoc1 – S. cerevisiae |
0.52 |
1.04E-08 |
8.30E-07 |
| An11g07490 |
similarity to alpha-1,6-mannosyltransferase Hoc1 – S. cerevisiae |
0.66 |
8.04E-07 |
2.46E-05 |
| An15g03330 |
strong similarity to galactosyltransferase Bed1 – S. cerevisiae |
1.42 |
9.62E-05 |
1.20E-03 |
| An11g09890* |
strong similarity to mannosyltransferase 1 PMT1 - Candida albicans |
1.36 |
1.27E-04 |
1.49E-03 |
| An07g10350* |
protein O-mannosyl transferase pmtA – A. niger |
1.50 |
4.45E-06 |
9.69E-05 |
|
An16g08490* |
strong similarity to dolichyl-phosphate-D-mannose--protein O-mannosyltransferase Pmt4 – S. cerevisiae |
1.49 |
1.89E-06 |
4.90E-05 |
|
An15g04810 |
similarity to alpha-1,3-mannosyltransferase Mnt2 - S. cerevisiae |
0.75 |
2.96E-05 |
4.66E-04 |
|
An02g11720 |
strong similarity to alpha-mannosidase msd2 – A. nidulans |
0.71 |
1.64E-05 |
2.85E-04 |
| An01g06500 |
strong similarity to filamentous growth protein Dfg5 – S. cerevisiae |
0.58 |
1.44E-05 |
2.56E-04 |
| An02g02660 |
strong similarity to hypothetical protein Dcw1 – S. cerevisiae |
0.78 |
2.74E-04 |
2.79E-03 |
| An11g01240* |
similarity to filamentous growth protein Dfg5 – S. cerevisiae |
2.17 |
1.48E-08 |
1.10E-06 |
|
Protein misfolding (UPR and ERAD associated degradation) | ||||
| An08g00830 |
strong similarity to protein phosphatase type 2C Ptc2 – S. cerevisiae |
1.31 |
5.07E-04 |
4.65E-03 |
|
An11g11250* |
strong similarity to interferon-induced double-stranded RNA-activated protein kinase inhibitor P58 - Homo sapiens |
1.80 |
2.58E-07 |
1.03E-05 |
|
An01g14100* |
weak similarity to stress protein Herp - Mus musculus |
1.61 |
1.12E-06 |
3.21E-05 |
|
An03g04340* |
strong similarity to ER membrane translocation facilitator Sec61 – Yarrowia lipolytica |
1.68 |
9.76E-08 |
4.9E-06 |
|
An04g00360* |
strong similarity to transport vesicle formation protein Sec13 – S. cerevisiae |
1.84 |
1.28E-08 |
9.9E-07 |
|
An15g00640* |
strong similarity to hypothetical protein GABA-A receptor epsilon subunit – Caenorhabditis elegans |
2.03 |
6.20E-08 |
3.53E-06 |
|
An16g07970* |
similarity to autocrine motility factor receptor Amfr – Mus musculus |
1.60 |
1.09E-05 |
2.02E-04 |
|
An12g00340* |
similarity to alpha 1,2-mannosidase IB - Homo sapiens |
1.54 |
7.61E-06 |
1.50E-04 |
|
An15g01420* |
strong similarity to glucosidase I Cwh41 – S. cerevisiae |
1.81 |
2.90E-08 |
1.84E-06 |
| An18g06220* |
strong similarity to alpha-mannosidase Mns1 – S. cerevisiae |
2.10 |
3.47E-06 |
8.05E-05 |
|
An01g12720* |
similarity to tumour suppressor protein TSA305 from patent WO9928457-A1 - Homo sapiens |
1.69 |
3.91E-07 |
1.38E-05 |
|
Protein complex involved in protein transport |
|
|
|
|
| An01g03190 |
similarity to protein Sec3 – S. cerevisiae |
1.30 |
7.93E-05 |
1.03E-03 |
| An08g05570* |
similarity to secretory protein Sec5 – S. cerevisiae |
1.54 |
1.97E-06 |
5.07E-05 |
| An04g06180 |
strong similarity to exocyst subunit Sec6 – S.s cerevisiae |
1.38 |
7.87E-05 |
1.03E-03 |
| An08g07370 |
similarity to exocyst protein Exo84 – S. cerevisiae |
1.42 |
9.83E-05 |
1.22E-03 |
| An02g14400* |
strong similarity to hypothetical protein SPCC338.13 – S. pombe |
1.43 |
8.59E-06 |
1.66E-04 |
| An16g01630 |
strong similarity to enoyl reductase of the lovastatin biosynthesis lovC – A.terreus |
0.35 |
1.66E-10 |
3.53E-08 |
|
An04g08690* |
similarity to polynucleotide sequence SEQ ID NO:3913 from patent WO200058473-A2 - Homo sapiens |
1.37 |
7.88E-05 |
1.03E-03 |
|
An02g07090* |
strong similarity to ASNA1 product arsenite translocating ATPase - Homo sapiens |
1.30 |
1.46E-04 |
1.66E-03 |
| An01g14250* |
strong similarity to delta subunit of the coatomer delta-coat protein CopD - Bos taurus |
1.46 |
3.66E-06 |
8.35E-05 |
| An08g01250* |
weak similarity to COP1-interacting protein 7 CIP7 - Arabidopsis thaliana |
1.75 |
4.69E-07 |
1.57E-05 |
| An16g05370* |
similarity to zinc-finger protein Glo3 - S. cerevisiae |
1.59 |
1.28E-05 |
2.34E-04 |
|
An16g02460* |
strong similarity to alpha subunit of the coatomer complex Ret1 – S. cerevisiae |
1.67 |
2.40E-07 |
9.68E-06 |
| An01g14260* |
strong similarity to delta subunit of the coatomer delta-coat protein CopD - Bos taurus [deleted ORF] |
1.51 |
1.15E-06 |
3.27E-05 |
| An12g04830* |
strong similarity to coatomer protein zeta chain Ret3 – S. cerevisiae |
1.47 |
7.15E-06 |
1.44E-04 |
|
An07g06030* |
strong similarity to coatomer gamma subunit 2 copg2 - Homo sapiens |
1.65 |
4.32E-06 |
9.45E-05 |
|
An02g05870* |
strong similarity to coatomer beta subunit copB2 - Homo sapiens [putative frameshift] |
1.50 |
1.17E-04 |
1.40E-03 |
| An01g04040* |
secretion-associated GTP-binding protein sarA – A. niger |
1.27 |
1.99E-04 |
2.13E-03 |
|
An08g03270* |
strong similarity to beta-COP Sec26 – S. cerevisiae |
1.48 |
2.84E-06 |
6.82E-05 |
|
An04g00360* |
strong similarity to transport vesicle formation protein Sec13 – S. cerevisiae |
1.84 |
1.28E-08 |
9.90E-07 |
|
An02g01690* |
strong similarity to p150 component of the COPII coat of secretory pathway vesicles Sec31 – S. cerevisiae |
1.60 |
2.05E-07 |
8.64E-06 |
|
An01g04730* |
strong similarity to secretory protein Sec23 – S. cerevisiae |
1.62 |
2.83E-07 |
1.08E-05 |
|
An08g10650* |
strong similarity to transport protein Sec24 – S. cerevisiae |
1.55 |
6.97E-07 |
2.18E-05 |
| An16g03320* |
strong similarity to transport protein Sec24A - Homo sapiens |
1.56 |
2.27E-06 |
5.69E-05 |
| An15g01520* |
strong similarity to multidomain vesicle coat protein Sec16 – S. cerevisiae |
1.53 |
1.74E-06 |
4.55E-05 |
|
ER to Golgi and intra-Golgi transport |
|
|
|
|
|
An08g03590* |
strong similarity to precursor of protein Emp24 – S. cerevisiae |
1.39 |
7.73E-06 |
1.52E-04 |
|
An09g05490* |
strong similarity to COP-coated vesicle membrane protein P24 homolog lbrA - Polysphondylium pallidum |
1.42 |
4.30E-06 |
9.43E-05 |
| An07g09160 |
strong similarity to pattern formation protein cni - Drosophila melanogaster |
1.28 |
1.30E-04 |
1.52E-03 |
| An01g08870* |
strong similarity to component of COPII-coated vesicles Erv25 - S. cerevisiae |
1.39 |
7.23E-06 |
1.45E-04 |
|
An08g03960* |
strong similarity to hypothetical endoplasmic reticulum associated protein – S. pombe |
1.55 |
7.36E-06 |
1.47E-04 |
|
An03g04940* |
strong similarity to Erv41 - S. cerevisiae |
2.12 |
1.20E-08 |
9.44E-07 |
|
An01g04320* |
strong similarity to COPII vesicle coat component protein Erv46 - S. cerevisiae |
2.12 |
7.61E-09 |
6.57E-07 |
|
An02g02830 |
strong similarity to protein RER1 - Homo sapiens |
1.30 |
5.22E-05 |
7.42E-04 |
|
An07g02190 |
strong similarity to protein Sec7 - S. cerevisiae |
1.44 |
9.50E-06 |
1.81E-04 |
|
An08g06780* |
strong similarity to transport protein Uso1 - S. cerevisiae |
1.52 |
2.93E-06 |
7.00E-05 |
| An18g06440 |
strong similarity to COPII vesicle component Yip3 - S. cerevisiae |
1.67 |
2.58E-06 |
6.30E-05 |
|
An04g01780* |
strong similarity to hypothetical protein YAR002c-a - S. cerevisiae |
1.54 |
1.03E-06 |
3.00E-05 |
|
An04g08830* |
similarity to Golgi membrane protein Emp47 - S. cerevisiae |
1.69 |
9.30E-07 |
2.78E-05 |
|
An02g04250* |
similarity to protein p58 - Rattus norvegicus |
1.77 |
2.01E-08 |
1.39E-06 |
|
An04g01990* |
similarity to protein ZW10 homolog HZW10 - Homo sapiens |
1.32 |
1.06E-04 |
1.29E-03 |
| An04g06090 |
similarity to geranylgeranyltransferase type-II alpha chain Bet4 - S. cerevisiae |
0.77 |
2.69E-04 |
2.75E-03 |
|
An08g00290* |
strong similarity to golgin-160 related protein Rud3 - S. cerevisiae |
1.52 |
1.11E-05 |
2.05E-04 |
|
An08g06330* |
strong similarity to epsilon-COP - Cricetulus griseus |
1.39 |
1.84E-05 |
3.14E-04 |
|
An07g07340* |
strong similarity to luminal ER-protein retention receptor ERD2 - Kluyveromyces marxianus |
1.65 |
2.00E-07 |
8.46E-06 |
|
Other processes in the secretory pathway |
|
|
|
|
|
An07g02170* |
similarity to transport protein Bos1 - S. cerevisiae |
1.91 |
1.65E-08 |
1.18E-06 |
| An15g01380* |
strong similarity to Synaptobrevin homolog v-SNARE Sec22 - S. cerevisiae |
1.30 |
2.74E-04 |
2.78E-03 |
|
An18g02490* |
strong similarity to ARF guanine-nucleotide exchange factor 2 Gea2 - S. cerevisiae |
1.31 |
1.52E-04 |
1.71E-03 |
| An07g08220* |
strong similarity to clathrin associated epsin 2A - Homo sapiens |
1.39 |
1.58E-05 |
2.76E-04 |
| An02g08450* |
secretory gene nsfA - Aspergillus niger |
1.27 |
2.86E-04 |
2.89E-03 |
| An02g14450* |
secretory pathway Ca2+−ATPase pmrA - Aspergillus niger |
1.51 |
3.12E-06 |
7.38E-05 |
| An16g08470* |
similarity to hypothetical cell growth regulator OS-9 - Homo sapiens |
1.76 |
8.57E-07 |
2.58E-05 |
|
An02g03460* |
similarity to hypothetical protein YIL041w - S. cerevisiae |
1.31 |
1.49E-04 |
1.68E-03 |
|
An04g02070 |
strong similarity to clathrin heavy chain - Bos taurus |
1.30 |
1.09E-04 |
1.33E-03 |
|
An06g01200* |
strong similarity to endosomal protein Emp70 - S. cerevisiae |
1.55 |
1.37E-06 |
3.77E-05 |
|
An01g11960 |
similarity to brefeldin A resistance protein Bfr1 - S. cerevisiae |
1.44 |
1.27E-05 |
2.33E-04 |
| An04g01950* | strong similarity to zinc-metalloprotease Ste24 - S. cerevisiae | 1.63 | 1.61E-07 | 7.12E-06 |