Table 2.
Examples of gene loci associated with T2DM, Hypothyroidism and related traits
| Gene locus | Full gene name | SNP | Associated phenotype | Odds ratio (95% CI) | p-value | Reference |
|---|---|---|---|---|---|---|
| PPARG |
Peroxisome proliferator-activated receptor gamma |
rs1801282 |
T2DM |
1.14 (1.08-1.20) |
1.7 × 10-6 |
Scott et al
[44]. |
| KCNJ11 |
Potassium inwardly rectifying channel, subfamily J, member 11 |
rs5219 |
T2DM |
1.14 (1.10-1.19) |
6.7 × 10-11 |
Scott et al
[44]. |
| TCF7L2 |
Transcription factor 7-like 2 |
rs7903146 |
T2DM, glucose, HbA1c |
1.37 (1.31-1.43) |
1.0 × 10-8 |
Sladek et al
[45]. |
| |
|
rs12255372 |
|
|
|
|
| SLC30A8 |
Solute carrier family 30 [zinc transporter], member 30 |
rs13266634 |
T2DM, HbA1c |
1.12 (1.07-1.16) |
5.3 × 10-8 |
Zeggini et al
[46]. |
| FTO |
Fat mass and obesity associated |
rs8050136 |
T2DM, BMI |
1.17 (1.12-1.22) |
1.3 × 10-12 |
Scott et al
[44]. |
| FOXE1 |
Forkhead box protein E1 |
rs965513 |
Thyroid cancer, TSH levels |
1.75 (1.49-2.01) |
1.7 × 10-27 |
Gudmundsson et al
[18]. |
| FOXE1 |
Forkhead box protein E1 |
rs7850258 |
Hypothyroidism |
0.74 (0.67-0.82) |
3.96 × 10-9 |
Denny et al
[47]. |
| PTPN22 |
Protein tyrosine phosphatase, non-receptor type 22 |
rs2476601 |
Hashimoto’s thyroiditis |
1.77 (1.31-2.40) |
4.6 × 10-13 |
Criswell et al
[20]. |
| VAV3 | Guanine nucleotide exchange factor | rs4915077 | Hypothyroidism | 1.397 (1.27-1.54) | 8.3 × 10-11 | Eriksson et al [48]. |