Figure 1. Increased clinical score in P.aeruginosa infected Lum ^−/− mice.

Mice were infected with 2×10⁴ CFU P.aeruginosa ATCC19660 in one eye and scored in a blinded manner for 6 days. A representative image of infected eyes 1 and 6 days post infection (d.p.i) shown for each genotype indicates relatively similar severity on day 1 but increased opacity and damage in the Lum ^−/− cornea on 6 d.p.i (A). Daily disease scores (B) of individual animals shows increased average scores for infected Lum ^−/− corneas.* p≤0.05.