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. 2013 Jan 24;8(1):e54797. doi: 10.1371/journal.pone.0054797

Figure 1. Effects of CXB analogues on Kv7.2/7.3 expressed in HEK293 cells.

Figure 1

A, Structures of CXB analogues. (a), Celecoxib (CXB); (b), unmethylated-celecoxib (UM-celecoxib, UMC); (c), 2, 5-Dimethyl-celecoxib (DM-celecoxib, DMC) B, The time course for the effects of CXB, UMC and DMC on the tail currents (−60 mV) of Kv7.2/7.3 recorded using the protocol shown at the top of the right panel. The representative current traces under different conditions of the treatments were shown at the right. The dotted line indicates the zero current level. C, Summarized data for the effects of CXB analogues on Kv7.2/7.3 channel. **P < 0.01, compared with the control current before application of CXB analgoues or retigabine (RTG). n = 3–6.