Table 1. Percentage of SNPs that are in linkage disequilibrium (r2>0.8) with a SNP predicted to be located on TFBS, splicing-affecting site, or miRNA binding site.
TFBS | Splicing | miRNA binding site | |
eQTL SNPs affecting expression levels in both whole blood and LCLs (37 SNPs) | 73.7% ‡ | 42.1% ‡ | 44.7% ‡ |
eQTL SNPs affecting expression levels in only whole blood (49 SNPs) | 58.8% ‡ | 43.1%‡ | 29.4% † |
non-eQTL SNPs (5,681 SNPs) | 34.8% | 17.3% | 14.1% |
The following abbreviations are used: TFBS, transcription factor binding site; miRNA, micro RNA; LCL, lymphoblastoid cell line.
P<0.01,
P<0.001: Significantly higher compared to non-eQTL SNPs (χ2 test).