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. 2013 Jan 24;8(1):e54692. doi: 10.1371/journal.pone.0054692

Figure 3. Inhibiting RhoA blocked proNGF-induced death in primary RGC cultures.

Figure 3

A,B. Representative images and statistical analysis showing ∼5-fold increase in TUNEL-positive cells in RGC-5 cells in response to mutant proNGF (50 ng/ml) (200× magnification). C,D. Representative images and statistical analysis showing ∼10-fold increase in TUNEL-positive cells in primary RGC cultures in response to mutant proNGF (50 ng/ml) (200× magnification). Co-treatment with Y27632 (1 µM) protected RGC in proNGF-treated group but had no effect on control cells. * = significant difference as compared with the rest of the groups at p<0.05 (n = 4). C, control; Y, Y27632.