Table 2. Mutational events in ETP-ALL compared to non-ETP T-ALL.
Mutation Status | ETP-ALL | non-ETP T-ALL | P-value | |
TCR rearrangement | monoclonal | 28 (41%) | 66 (79%) | <.001 |
n = 153 | polyclonal | 40 (59%) | 18 (21%) | |
NOTCH1 | mut | 10 (15%) | 35 (41%) | <.001 |
n = 151 | wt | 56 (85%) | 50 (59%) | |
FLT3 total | mut | 24 (35%) | 1 (1%) | <.001 |
n = 153 | wt | 44 (65%) | 84 (99%) | |
FLT3 ITD | mut | 15 (22%) | 0 (0%) | <.001 |
wt | 53 (78%) | 85 (100%) | ||
FLT3 D835 | mut | 9 (13%) | 1 (1%) | .003 |
wt | 59 (87%) | 84 (99%) |
P values were calculated by Pearson's Chi-square test and Fisher's exact test, respectively.