Table 4. Molecular characteristics of FLT3mut ETP-ALL versus FLT3wt ETP-ALL patients.
A Expression | FLT3mut (n = 24) | FLT3wt (n = 44) | P-value | |
WT1 | median (range) | 0.78 (0.2–4.2) | 0.36 (0.0–3.4) | .003 |
IGFBP7 | median (range) | 0.30 (0.02–4.0) | 2.52 (0.1–9.9) | <.001 |
GATA3 | median (range) | 0.06 (0.0–5.7) | 5.82 (0.0–6.7) | <.001 |
BAALC | median (range) | 0.44 (0.01–17.7) | 0.95 (0.0–27.1) | .41 |
ERG | median (range) | 0.94 (0.2–18.6) | 1.56 (0.0–4.2) | .16 |
MN1 | median (range) | 6.35 (0.3–16.8) | 7.42 (0.0–33.1) | .29 |
BCL11B | median (range) | 0.20 (0.0–1.4) | 0.05 (0.0–1.0) | .09 |
MEF2C | median (range) | 0.71 (0.02–2.2) | 0.46 (0.0–5.1) | .22 |
B Mutation Status | ||||
NOTCH1 | mut | 0 (0%) | 10 (23%) | .01 |
wt | 24 (100%) | 34 (77%) | ||
TCR status | monoclonal | 5 (21%) | 23 (52%) | .01 |
polyclonal | 19 (79%) | 21(48%) |
A: P-values were calculated by Mann-Whitney-U-test.
B: P-values were calculated by Pearson's Chi-square test and Fisher's exact test, respectively.