Figure 4. Relationship between nevirapine trough concentration and baseline liver function.

The nevirapine trough concentration at week 2 in patients with baseline ALT level <1.5×ULN was significant lower than those with ALT ≥1.5×ULN at baseline (P = 0.045). No significant difference was observed between lead-in and steady-state periods in patients with (A) ALT level ≥1.5×ULN (P = 0.171) and (B) AST level ≥1.5×ULN (P = 0.769) at baseline.