Table 3. Univariate and multivariate logistic model to examine risk factors to predict nevirapine trough concentration lower than recommended thresholds at week 2.

	Univariate 1			Univariate 2			Multivariate 1			Multivariate 2
	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value
male	1.569	0.840–2.928	0.155	1.132	0.645–1.987	0.666	0.576	0.280–1.183	0.133	0.967	0.512–1.827	0.919
Age ≥50	1.668	0.706–3.943	0.240	1.128	0.582–2.186	0.721	0.992	0.963–1.022	0.598	1.009	0.984–1.034	0.488
Weight ≥50 Kg	0.512	0.215–1.217	0.124	0.774	0.340–1.760	0.540	1.004	0.971–1.037	0.833	0.984	0.956–1.012	0.262
Baseline ALT level ≥1.5×ULN	1.830	0.610–5.491	0.275	1.813	0.766–4.292	0.171	1.002	0.980–1.024	0.867	1.005	0.987–1.023	0.581
Baseline AST level ≥1.5×ULN	0.973	0.306–3.093	0.964	1.035	0.382–2.801	0.946	0.996	0.965–1.028	0.821	0.990	0.965–1.016	0.465
Baseline CD4 counts ≥250 cells/µL	0.706	0.387–1.287	0.254	0.878	0.515–1.495	0.631	1.001	0.998–1.004	0.601	1.000	0.998–1.003	0.809
Baseline viral load ≥5 log10 copies	0.847	0.458–1.567	0.597	0.894	0.524–1.525	0.681	1.344	0.888–2.035	0.163	1.137	0.812–1.593	0.455
HBV co-infection	0.554	0.260–1.179	0.122	0.776	0.385–1.564	0.477
HCV co-infection	1.241	0.542–2.842	0.610	0.965	0.491–1.898	0.918

Univariate 1 and multivariate 1: The recommended cut-off value was 3.0 µg/mL.

Univariate 2 and multivariate 2: The recommended cut-off value was 3.9 µg/mL.

ALT: alanine aminotransferase; AST: aspartate aminotransferase.